Scientific Publications

CS1-related

Exploratory outcomes of CS1 in Pulmonary Arterial Hypertension: Phase 2A, Prospective, Randomized, Open-Label, Multicenter Trial

Raymond L. Benza, Marc A. Simon, Selim R. Krim, H. James Ford, Tatiane Abreu Dall'Agnol, Sandhya Murthy, Evelyn Horn, Jason L. Guichard. 4th Balthic Conference on May 9, 2025. [Abstract Book, page 11]

Investigation of efficacy, safety and optimal dose of CS1 in subjects with pulmonary arterial hypertension: a prospective, randomized, multicenter, parallel-group phase II study

Raymond Benza, Niklas Bergh, Philip Adamson, Björn Dahlöf. PVRI congress 2022.

A First in Class Treatment for Thrombosis Prevention. A Phase I study with CS1, a New Controlled Release Formulation of Sodium Valproate

Niklas Bergh, Jan-Peter Idström, Henri Hansson, Jonas Faijerson-Säljö, Björn Dahlöf. Journal of Cardiology and Vascular Medicine 2019 Volume 5: 1-12.

CS014-related

Novel HDAC inhibitor, CS014, attenuates in vivo thrombosis while maintaining hemostasis

Stanger L, Yalavarthi P, Adili R, Gilmore D, Hoang T, Campbell A, Krenik P, Gustafsson D, Fryklund J, Fex T, Oakes N, Säljö JF, Dahlöf B, Beckman J, Holinstat M. Journal of Thrombosis and Haemostasis (2026), doi: https://doi.org/10.1016/j.jtha.2025.11.011.

HDACi, CS014, dose-dependently reverses vascular remodeling in a preclinical model of pulmonary arterial hypertension [poster presentation]

Tatiane Abreu Dall’Agnol, Fredrik Frick, Rahul Agrawal, Björn Dahlöf, Nicholas Oakes. Presented at Pharmacology 2025, December 16-18, Belfast, Ireland.

Safety, tolerability, and pharmacokinetics of the novel HDAC inhibitor CS014: a first-in-human trial [oral presentation]

Tatiane Abreu Dall’Agnol, Fredrik Frick, Rahul Agrawal, Björn Dahlöf, Johan Nilsson, Johan Bylund, Erik Westrin, Nicholas Oakes. Presented at Pharmacology 2025, December 16-18, Belfast, Ireland.

CS014, a Novel Precision Deuterated VPA with HDAC Inhibitor Properties, Demonstrates Preclinical Efficacy in Pulmonary Vascular Disease and Clinical Safety [poster presentation]

Tatiane A. Dall’Agnol, Fredrik Frick, Rahul Agrawal, Björn Dahlöf, Johan Nilsson, Johan Bylund, Erik Westrin, Nicholas Oakes. Presented at PVRI 2026, January 28-February 1, in Dublin, Ireland.

Epigenetic modulation and HDAC inhibition

Histone deacetylase inhibitors for cardiovascular conditions and healthy longevity.

João Pedro Ferreira, Bertram Pitt, Faiez Zannad. The Lancet Healthy Longevity, Volume 2, Issue 6, 2021, pages e371-e379, ISSN 2666-7568, doi.org/10.1016/S2666-7568(21)00061-1.

CS585-related

CS585 is a first-in-class compound targeting the IP receptor for prevention of thrombosis without increased risk of bleeding

Sylviane Lambert, Reheman Adili, Pooja Yalavarthi, Nicole Rhoads, Björn Dahlöf, Andrew White, Niklas Bergh, Michael Holinstat. HemaSphere, 2022; 6:S3.

CS585 is a novel orally available prostacyclin receptor agonist with sustained in vivo inhibition of platelets and thrombosis formation in mouse without increased risk of bleeding

Sylviane Lambert, Pooja Yalavarthi, Livia Stanger, Adriana Yamaguchi, Michael Holinstat, Niklas Bergh, Björn Dahlöf. ACC.23/WCC Congress 2023.

Scientific publications

Investigation of efficacy, safety and optimal dose of CS1 in subjects with pulmonary arterial hypertension: a prospective, randomized, multicenter, parallel-group phase II study

A First in Class Treatment for Thrombosis Prevention. A Phase I study with CS1, a New Controlled Release Formulation of Sodium Valproate

HDACi, CS014, dose-dependently reverses vascular remodeling in a preclinical model of pulmonary arterial hypertension [poster presentation]

Safety, tolerability, and pharmacokinetics of the novel HDAC inhibitor CS014: a first-in-human trial [oral presentation]

CS014, a Novel Precision Deuterated VPA with HDAC Inhibitor Properties, Demonstrates Preclinical Efficacy in Pulmonary Vascular Disease and Clinical Safety [poster presentation]

CS585 is a novel orally available prostacyclin receptor agonist with sustained in vivo inhibition of platelets and thrombosis formation in mouse without increased risk of bleeding